Synthesis, Characterization and Antimicrobial Activities of Schiff bases of 2-amino-4-(O-chloroanilino)-1, 3-thiazole.

A novel series of schiff bases of 2-amino-4-(o-chloro anilino)-1, 3-thiazole (3a-3j) were synthesized and screened for their antibacterial and antifungal activities. The structures of these compounds were ascertained by UV, IR, 1H NMR, mass spectra and elemental analysis. The antibacterial activity of the synthesized schiff bases were evaluated against Gram positive bacteria such as Staphylococcus aureus, Bacillus subtilis and Gram negative bacteria like Escherichia coli and Klebsiella pneumonia. All the compounds had shown moderate to significant antibacterial activity amongst them; compound 3e exhibited more significant activity against the tested bacteria. The antifungal activity was screened against two strains of fungi such as Candida albicans and Aspergillus niger. Similar to antibacterial activity compound 3e exhibited significant antifungal activity. The standard drugs Amoxycillin and Amphotericin B were used to screen antibacterial and antifungal activity at 10μg/ml respectively. Interestingly compound 3e had shown more prominent inhibitory activity against the tested bacteria and fungi.

Relationship of intestinal parasitism, malaria and under-nutrition to prevalence of anaemia in an urban community.

The presence of intestinal parasitic infection, malaria and under-nutrition in relation to prevalence of anaemia was evaluated in a cluster of urban population in Hyderabad. Prevalence of anaemia was 25.7 per cent by clinical assessment from pallor as against 80.5 per cent by estimation of haemoglobin concentration. Presence of intestinal parasitic infection (48.4 per cent) and malaria infection (18.3 per cent) had no statistical significant association with anaemic state. Under-nutrition (31.9 per cent of anaemic individuals) and low per capita monthly income of Rs. 100 and below (60.9 per cent of enaemic individuals) had a statistically significant relationship to anaemia. Clinical assessment of anaemia from pallor had a low sensitivity (31.9 per cent) and a high false negative rate (54.9 per cent), though clinical pallor had a strong statistical association to the presence of anaemia. (p less than 10.01), (Q = 1.0).